Journal Article

FZJ-2024-05143

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The Effects of Electric Fields on Protein Phase Behavior and Protein Crystallization Kinetics

Ray, D. (First author)FZJ* ; Madani, M. ; Dhont, J. K. G.FZJ* ; Platten, F. (Corresponding author)FZJ* ; Kang, K. (Corresponding author)FZJ*

2024
ACS Washington, DC

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Please use a persistent id in citations: doi:10.1021/acs.jpclett.4c01744  doi:10.34734/FZJ-2024-05143

Abstract: We experimentally studied the effects of an externally applied electric field on protein crystallization and liquid–liquid phase separation (LLPS) and its crystallization kinetics. For a surprisingly weak alternating current (AC) electric field, crystallization was found to occur in a wider region of the phase diagram, while nucleation induction times were reduced, and crystal growth rates were enhanced. LLPS on the contrary was suppressed, which diminishes the tendency for a two-step crystallization scenario. The effect of the electric field is ascribed to a change in the protein–protein interaction potential.

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Contributing Institute(s):

1. Biomakromolekulare Systeme und Prozesse (IBI-4)

Research Program(s):

1. 5241 - Molecular Information Processing in Cellular Systems (POF4-524) (POF4-524)
2. DFG project 495795796 - Das Phasenverhalten von Proteinlösungen in elektrischen Feldern (495795796) (495795796)

Appears in the scientific report 2024

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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