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| Home > Publications database > Longitudinal trajectories of resilient psychosocial functioning link to ongoing cortical myelination and functional reorganization during adolescence |
| Home > Publications database > Longitudinal trajectories of resilient psychosocial functioning link to ongoing cortical myelination and functional reorganization during adolescence |
| Preprint | FZJ-2025-01527 |
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2024
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Please use a persistent id in citations: doi:10.31234/osf.io/2dv68 doi:10.34734/FZJ-2025-01527
Abstract: Adolescence is a period of dynamic brain remodeling and susceptibility to psychiatric risk factors, mediated by the protracted consolidation of association cortices. Here, we investigated whether intra-individual trajectories of psychosocial functioning relative to environmental stressor exposure - including adverse life events, dysfunctional family settings, and socio-economic status - are tied to myeloarchitectural maturation and down-stream effects on intrinsic function. To this end, we employed longitudinal myelin-sensitive Magnetic Transfer (MT) and resting-state imaging in the NSPN cohort (aged 14-26y). Developing towards more resilient psychosocial functioning was linked to increasing myelination in the anterolateral prefrontal cortex, which exhibited stabilized functional connectivity. Studying depth-specific intracortical MT profiles and the cortex-wide synchronization of myeloarchitectural maturation, we further observed wide-spread myeloarchitectural re-configuration of association cortices paralleled by attenuated functional reorganization with increasingly resilient outcomes. Together, trajectories of resilient/susceptible psychosocial functioning showed considerable intra-individual change reflected in multi-modal cortical refinement processes at the local and system-level.
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