Journal Article

FZJ-2025-04518

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Comparison of standard and modified 99Mo/99mTc radionuclide generators

Michel, M. (Corresponding author) ; Sudbrock, F. ; Neumaier, B.FZJ* ; Eberhardt, K. ; Strub, E.

2025
Springer Science + Business Media B.V. Dordrecht [u.a.]

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Please use a persistent id in citations: doi:10.1007/s10967-025-10423-5  doi:10.34734/FZJ-2025-04518

Abstract: 99mTc is the most widely used radionuclide in medical diagnostics and typically obtained from high-specific-activity (HSA) 99Mo produced in nuclear reactors. However, recent reactor shutdowns have led to supply shortages and prompted efforts to implement alternative production methods. One promising approach is neutron activation of 98Mo, which yields low-specific-activity (LSA) 99Mo. Since conventional Al2O3-based 99Mo/99mTc generators are designed for HSA 99Mo, adaptations are required for LSA 99Mo usage. In this study, we evaluated the feasibility of modifying existing Al2O3-based 99Mo/99mTc generators for use with LSA 99Mo, anticipating production at the planned high brilliance neutron source (HBS) at Forschungszentrum Jülich. Key modifications included adjustments to the amount of Al2O3 on the column and the elution volume of 99mTc to enhance 99Mo adsorption and 99mTc elution efficiency. The performance of the modified “mock-up” system was compared with a standard clinical generator. The results demonstrated that only minor modifications are required for LSA 99Mo to be effectively utilized in a future generator, with elution efficiencies remaining comparable to conventional generators, while maintaining parameters like size, form, number, activity of the individual generator comparable. However, 99Mo breakthrough levels exceeded regulatory limits, highlighting the need for further optimization. Nevertheless, these findings support the feasibility of using LSA 99Mo in clinical applications with minimal changes to existing infrastructure.

Note: This work is part of the ‘99MoBest’ joint projectand was funded by the Federal Ministry of Education and Research(BMBF) under funding number 02NUK080A.

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Contributing Institute(s):

1. Nuklearchemie (INM-5)

Research Program(s):

1. 5253 - Neuroimaging (POF4-525) (POF4-525)

Appears in the scientific report 2025

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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