Journal Article

FZJ-2026-02136

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Intracortical microstructure profiling: a cross-modal method for indexing cortical lamination

Paquola, C. (Corresponding author)FZJ* ; Royer, J. ; Tsigaras, T.FZJ* ; Cabalo, D. ; Hwang, Y. ; Hoffstaedter, F.FZJ* ; Eickhoff, S.FZJ* ; Bernhardt, B.

2026
MIT Press Cambridge, MA

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Please use a persistent id in citations: doi:10.1162/IMAG.a.1212  doi:10.34734/FZJ-2026-02136

Abstract: Intracortical microstructure profiling represents a powerful, scalable approach for investigating the laminar organisation of the human cortex on both in-vivo and post-mortem datasets. Building upon a long tradition of histological analysis, this method leverages surface-based intracortical sampling to generate profiles of tissue properties across cortical depths. The present work outlines a standardised workflow for intracortical microstructural profiling, newly packaged as the open-source toolbox “CortPro” (https://github.com/caseypaquola/cortpro). Here, we explore the utility of central moments as descriptors of profile shape. Using these measures, we quantify (i) the extent to which in-vivo MRI can capture laminar differentiation, (ii) the test-retest reliability of profiles, and (iii) their replicability across sites and studies. Our results demonstrate that intracortical profiles are remarkably robust and effectively mitigate bias-field related limitations of non-quantitative MRI. As applications of microstructure-sensitive imaging expand across development, aging, and disease, microstructure profiling provides a principled means of linking microstructural neuroanatomy with systems-level brain organisation.

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Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)

Appears in the scientific report 2026

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