Journal Article

FZJ-2026-05913

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Membrane remodelling mediates lipopeptide-induced immunity in Arabidopsis

Gilliard, G. ; Pršić, J. ; Crowet, J.-M. ; Chemotti, C. ; Ahmed, J. ; Lorent, J. ; Jolivet, M.-D. ; Egli, S. ; Egée, S. ; Bouyer, G. ; Race, G. ; van Buren, L. ; Van Den Berghe, A. ; Argüelles-Arias, A. ; Mathelié-Guinlet, M. ; Ibrahim, H.FZJ* ; Genva, M. ; Fouillen, L. ; Mirande-Bret, C. ; Razin, O. ; Vue, B. ; Župunski, M. ; Luzuriaga-Loaiza, W. P. ; Deboever, E. ; Nasir, M. N. ; Lins, L. ; Van Der Smissen, P. ; Boubsi, F. ; Eschrig, S. ; Germain, V. ; Höfte, M. ; Zipfel, C. ; Dufrêne, Y. F. ; Tyteca, D. ; Koutsioumpas, A.FZJ* ; Brocca, P. ; Grossmann, G. ; Ranf, S. ; Dorey, S. ; De Coninck, B. ; Nürnberger, T. ; Mongrand, S. ; Gronnier, J. ; Rondelli, V. ; Deleu, M. (Corresponding author) ; Ongena, M. (Corresponding author)

2026
Nature Publ. Group London

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Please use a persistent id in citations: doi:10.1038/s41477-026-02270-3  doi:10.34734/FZJ-2026-05913

Abstract: Bacteria-derived lipopeptides are immunogenic triggers of host defences in metazoans and plants. Root-associated rhizobacteria produce cyclic lipopeptides that activate induced systemic resistance against microbial infection in various plant species. Whether and how these molecules are perceived at the plant cell surface remains elusive. Here we reveal that immune activation in Arabidopsis thaliana by the lipopeptide elicitor surfactin is mediated via a specific interaction with membrane sphingolipids. It relies on host membrane remodelling and subsequent activation of mechanosensitive ion channels. This mechanism leads to host defence potentiation and resistance to the necrotrophic fungus Botrytis cinerea and appears distinct from pattern-triggered immunity induced by classical host pattern recognition receptors. These results reveal a previously uncharacterized mechanism through which lipopeptides derived from non-pathogenic bacteria activate plant immune responses.

Keyword(s): Health and Life (1st) ; Biology (2nd)

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Contributing Institute(s):

1. JCNS-FRM-II (JCNS-FRM-II)
2. JCNS-4 (JCNS-4)
3. Heinz Maier-Leibnitz Zentrum (MLZ)

Research Program(s):

1. 6G4 - Jülich Centre for Neutron Research (JCNS) (FZJ) (POF4-6G4) (POF4-6G4)
2. 633 - Life Sciences – Building Blocks of Life: Structure and Function (POF4-633) (POF4-633)

Experiment(s):

1. MARIA: Magnetic reflectometer with high incident angle (NL5N)

Appears in the scientific report 2026

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Agriculture, Biology and Environmental Sciences ; DEAL Nature ; Essential Science Indicators ; IF >= 15 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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