Journal Article

PreJuSER-11234

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Cognitive levels of performance account for hemispheric lateralisation effects in dyslexic and normally reading children

Heim, S.FZJ* ; Grande, M. ; Meffert, E.FZJ* ; Eickhoff, S. B.FZJ* ; Schreiber, H.FZJ* ; Kukolja, J.FZJ* ; Shah, J. N.FZJ* ; Huber, W. ; Amunts, K.FZJ*

2010
Academic Press Orlando, Fla.

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Please use a persistent id in citations: doi:10.1016/j.neuroimage.2010.07.009

Abstract: Recent theories of developmental dyslexia explain reading deficits in terms of deficient phonological awareness, attention, visual and auditory processing, or automaticity. Since dyslexia has a neurobiological basis, the question arises how the reader's proficiency in these cognitive variables affects the brain regions involved in visual word recognition. This question was addressed in two fMRI experiments with 19 normally reading children (Experiment 1) and 19 children with dyslexia (Experiment 2). First, reading-specific brain activation was assessed by contrasting the BOLD signal for reading aloud words vs. overtly naming pictures of real objects. Next, ANCOVAs with brain activation during reading the individuals' scores for all five cognitive variables assessed outside the scanner as covariates were performed. Whereas the normal readers' brain activation during reading showed co-variation effects predominantly in the right hemisphere, the reverse pattern was observed for the dyslexics. In particular, middle frontal gyrus, inferior parietal cortex, and precuneus showed contralateral effects for controls as compared to dyslexics. In line with earlier findings in the literature, these data hint at a global change in hemispheric asymmetry during cognitive processing in dyslexic readers, which, in turn, might affect reading proficiency.

Keyword(s): Brain: physiology (MeSH) ; Brain Mapping (MeSH) ; Child (MeSH) ; Cognition: physiology (MeSH) ; Dyslexia: physiopathology (MeSH) ; Female (MeSH) ; Functional Laterality: physiology (MeSH) ; Humans (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Male (MeSH) ; Reading (MeSH) ; J

Note: This research was supported by the German Federal Ministry of Education and Research (BMBF 01GJ0613 to S.H. and BMBF 01GJ0614 to M.G.), the National Institute of Biomedical Imaging and Bioengineering, the National Institute of Neurological Disorders and Stroke, and the National Institute of Mental Health (K.A.).

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)
2. Strukturelle und funktionelle Organisation des Gehirns (INM-1)
3. Molekulare Organisation des Gehirns (INM-2)
4. Jülich-Aachen Research Alliance - Translational Brain Medicine (JARA-BRAIN)
5. Physik der Medizinischen Bildgebung (INM-4)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (FUEK409) (FUEK409)
2. 89572 - (Dys-)function and Plasticity (POF2-89572) (POF2-89572)

Appears in the scientific report 2010

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