Journal Article

FZJ-2014-03593

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Prepulse Inhibition of the Acoustic Startle Reflex in High Functioning Autism

Kohl, S. ; Wolters, C. ; Gruendler, T. O. J. ; Vogeley, K.FZJ* ; Klosterkötter, J. ; Kuhn, J.

2014
PLoS Lawrence, Kan.

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Please use a persistent id in citations: http://hdl.handle.net/2128/7822  doi:10.1371/journal.pone.0092372

Abstract: High functioning autism is an autism spectrum disorder that is characterized by deficits in social interaction and communication as well as repetitive and restrictive behavior while intelligence and general cognitive functioning are preserved. According to the weak central coherence account, individuals with autism tend to process information detail-focused at the expense of global form. This processing bias might be reflected by deficits in sensorimotor gating, a mechanism that prevents overstimulation during the transformation of sensory input into motor action. Prepulse inhibition is an operational measure of sensorimotor gating, which indicates an extensive attenuation of the startle reflex that occurs when a startling pulse is preceded by a weaker stimulus, the prepulse.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 333 - Pathophysiological Mechanisms of Neurological and Psychiatric Diseases (POF2-333) (POF2-333)
2. 89572 - (Dys-)function and Plasticity (POF2-89572) (POF2-89572)

Appears in the scientific report 2014

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Database coverage:
; ; ; ; BIOSIS Previews ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection ; Zoological Record

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