Journal Article

FZJ-2014-03787

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Softening of phospholipid membranes by the adhesion of silica nanoparticles – as seen by neutron spin-echo (NSE)

Hoffmann, I. (Corresponding Author) ; Michel, R. ; Sharp, M. ; Holderer, O.FZJ* ; Appavou, M.-S.FZJ* ; Polzer, F. ; Farago, B. ; Gradzielski, M.

2014
RSC Publ. Cambridge

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Please use a persistent id in citations: http://hdl.handle.net/2128/5825  doi:10.1039/c4nr00774c

Abstract: The interactions between nanoparticles and vesicles are of significant interest both from a fundamental as well as from a practical point of view, as vesicles can serve as a model system for cell membranes. Accordingly the effect of nanoparticles that bind to the vesicle bilayer is very important with respect to understanding their biological impact and also may shed some light on the mechanisms behind the effect of nanotoxicity. In this study we have investigated the influence of small adsorbed silica nanoparticles (SiNPs) on the structure of zwitterionic DOPC vesicles. By a combination of SANS, cryo-TEM, and DLS, we observed that the SiNPs are bound to the outer vesicle surface without significantly affecting the vesicle structure. Most interestingly, by means of neutron spin-echo (NSE) local bilayer fluctuations were studied and one finds a small but marked decrease of the membrane rigidity upon binding of the nanoparticles. This surprising finding may be a relevant aspect for the further understanding of the effects that nanoparticles have on phospholipid bilayers

Keyword(s): Health and Life (1st) ; Health and Life (1st) ; Soft Matter, Macromolecules, Complex fluids, Biophysics (1st) ; Soft Condensed Matter (2nd)

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Contributing Institute(s):

1. Neutronenstreuung (Neutronenstreuung ; JCNS-1)
2. JCNS-FRM-II (JCNS (München) ; Jülich Centre for Neutron Science JCNS (München) ; JCNS-FRM-II)
3. Neutronenstreuung (ICS-1)

Research Program(s):

1. 451 - Soft Matter Composites (POF2-451) (POF2-451)
2. 54G - JCNS (POF2-54G24) (POF2-54G24)

Experiment(s):

1. J-NSE: Neutron spin-echo spectrometer (NL2ao)
2. KWS-2: Small angle scattering diffractometer (NL3ao)

Appears in the scientific report 2014

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Database coverage:
; ; ; Current Contents - Life Sciences ; JCR ; NCBI Molecular Biology Database ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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