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| Home > Publications database > Serotonin 5-HT1A Receptor Binding Sites in the Brain of the Pigeon (Columba livia) |
| Home > Publications database > Serotonin 5-HT1A Receptor Binding Sites in the Brain of the Pigeon (Columba livia) |
| Journal Article | PreJuSER-17573 |
; ; ;
2012
Elsevier Science
Amsterdam [u.a.]
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Please use a persistent id in citations: doi:10.1016/j.neuroscience.2011.10.050
Abstract: Present knowledge about the serotonergic system in birdbrains is very limited, although the pigeon was used as an animal model in various studies focused on the behavioral effects of serotonergic transmission. In the mammalian brain the 5-HT(1A) receptor is the most widespread serotonin receptor type, and is involved in various functions. Less is known about the distribution of 5-HT(1A) receptors in the avian species. Therefore, we analyzed serotonin 5-HT(1A) receptor binding sites in the pigeon brain using quantitative in vitro receptor autoradiography with the selective radioligand [³H]-8-hydroxy-2-(di-n-propylamino)tetralin ([³H]-8-OH-DPAT). The receptor is differentially distributed throughout the pigeon brain. High levels of 5-HT(1A) receptors are found in the nucleus pretectalis (PT). Moderate densities were detected in the tectum, as well as in the telencephalic nidopallium and hyperpallium. Very low levels were found in the hippocampal formation, the amygdaloid complex, the basal ganglia, and several thalamic nuclei. Furthermore, local variations in 5-HT(1A) receptor densities support the concept of further subdivisions of the entopallium. The regional distribution patterns of 5-HT(1A) receptors mostly display a similar distribution as found in homologue brain structures of mammals.
Keyword(s): 8-Hydroxy-2-(di-n-propylamino)tetralin: pharmacokinetics (MeSH) ; Analysis of Variance (MeSH) ; Animals (MeSH) ; Autoradiography (MeSH) ; Binding Sites: drug effects (MeSH) ; Binding Sites: physiology (MeSH) ; Brain: drug effects (MeSH) ; Brain: metabolism (MeSH) ; Brain Mapping (MeSH) ; Columbidae (MeSH) ; Receptors, Serotonin, 5-HT1: metabolism (MeSH) ; Serotonin Receptor Agonists: pharmacokinetics (MeSH) ; Tritium: pharmacokinetics (MeSH) ; Receptors, Serotonin, 5-HT1 ; Serotonin Receptor Agonists ; Tritium ; 8-Hydroxy-2-(di-n-propylamino)tetralin ; J ; 5-HT1A receptor (auto) ; [H-3]-8-OH-DPAT (auto) ; avian (auto) ; nucleus pretectalis (auto) ; entopallium (auto) ; MVL (auto)
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