Journal Article

PreJuSER-18196

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Cubosomes for Ruthenium complex delivery: formulation and characterization

Mangiapia, G. ; Vaccaro, M. ; D'Errico, G. ; Frielinghaus, H.FZJ* ; Radulescu, A.FZJ* ; Pipich, V.FZJ* ; Carnerup, A. M. ; Paduano, L.

2011
Royal Society of Chemistry (RSC) Cambridge

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Please use a persistent id in citations: http://hdl.handle.net/2128/7361  doi:10.1039/C1SM06323E

Abstract: An amphiphilic ruthenium-based molecule (DOPURu) with potential antineoplastic activity has been synthesized, and its aggregation behavior in the presence of phospholipids has been investigated. A very rich variety of aggregates has been found, spanning from vesicles to cubic bicontinuous phases. Cubosomes here presented represent one of the first systems with potential use for medical therapy.

Keyword(s): Health and Life (1st) ; Health and Life (1st) ; Medicine (2nd) ; J

Note: The work was supported by MIUR (PRIN 2008-prot. 20087K9A2J). The authors thank the Forschungszentrum Julich for provision of beam time. SANS experiments were supported by the European Commission, NMI3 contract RII3-CT-2003-505925. The authors thank Prof. Viveka Alfredsson for critical assessment of the results obtained through Cryo-TEM images.

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Contributing Institute(s):

1. Neutronenstreuung (ICS-1)
2. JCNS-FRM-II (JCNS (München) ; Jülich Centre for Neutron Science JCNS (München) ; JCNS-FRM-II)
3. Neutronenstreuung (JCNS-1)
4. Streumethoden (JCNS-2)

Research Program(s):

1. BioSoft: Makromolekulare Systeme und biologische Informationsverarbeitung (P45)
2. Großgeräte für die Forschung mit Photonen, Neutronen und Ionen (PNI) (P55)

Experiment(s):

1. KWS-2: Small angle scattering diffractometer (NL3ao)

Appears in the scientific report 2011

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Database coverage:

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