Journal Article

FZJ-2015-01443

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Sensing with nanopores – the influence of asymmetric blocking on electrochemical redox cycling current

Krause, K. J. (Corresponding Author)FZJ* ; Kätelhön, E. ; Lemay, S. G. ; Compton, R. G. ; Wolfrum, B.FZJ*

2014
Soc. Cambridge

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Please use a persistent id in citations: http://hdl.handle.net/2128/8399  doi:10.1039/C4AN01401D

Abstract: Nanoporous redox cycling devices are highly efficient tools for the electrochemical sensing of redox-active molecules. By using a redox-active mediator, this concept can be exploited for the detection of molecular binding events via blocking of the redox cycling current within the nanopores. Here, we investigate the influence of different blocking scenarios inside a nanopore on the resulting redox cycling current. Our analysis is based on random walk simulations and finite element calculations. We distinguish between symmetric and asymmetric pore blocking and show that the current decrease is more pronounced in the case of asymmetric blocking reflecting the diffusion-driven pathway of the redox-active molecules. Using random walk simulations, we further study the impact of pore blocking in the frequency domain and identify relevant features of the power spectral density, which are of particular interest for sensing applications based on fluctuation analysis.

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Contributing Institute(s):

1. Bioelektronik (PGI-8)
2. JARA-FIT (JARA-FIT)

Research Program(s):

1. 423 - Sensorics and bioinspired systems (POF2-423) (POF2-423)

Appears in the scientific report 2014

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Database coverage:
; ; Allianz-Lizenz / DFG ; Current Contents - Life Sciences ; Current Contents - Physical, Chemical and Earth Sciences ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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