Journal Article

FZJ-2015-04028

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Complementary Metal Oxide Semiconductor Compatible Silicon Nanowires-on-a-Chip: Fabrication and Preclinical Validation for the Detection of a Cancer Prognostic Protein Marker in Serum

Tran, D. P. (Corresponding Author)FZJ* ; Wolfrum, B.FZJ* ; Stockmann, R.FZJ* ; Pai, J.-H. ; Pourhassan-Moghaddam, M. ; Offenhäusser, A. (Corresponding Author)FZJ* ; Thierry, B.

2015
American Chemical Society Columbus, Ohio

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Please use a persistent id in citations: doi:10.1021/ac503374j

Abstract: An integrated translational biosensing technology based on arrays of silicon nanowire field-effect transistors (SiNW FETs) is described and has been preclinically validated for the ultrasensitive detection of the cancer biomarker ALCAM in serum. High-quality SiNW arrays have been rationally designed toward their implementation as molecular biosensors. The FET sensing platform has been fabricated using a complementary metal oxide semiconductor (CMOS)-compatible process. Reliable and reproducible electrical performance has been demonstrated via electrical characterization using a custom-designed portable readout device. Using this platform, the cancer prognostic marker ALCAM could be detected in serum with a detection limit of 15.5 pg/mL. Importantly, the detection could be completed in less than 30 min and span a wide dynamic detection range (∼105). The SiNW-on-a-chip biosensing technology paves the way to the translational clinical application of FET in the detection of cancer protein markers.

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Contributing Institute(s):

1. Bioelektronik (PGI-8)
2. Bioelektronik (ICS-8)
3. JARA-FIT (JARA-FIT)

Research Program(s):

1. 523 - Controlling Configuration-Based Phenomena (POF3-523) (POF3-523)

Appears in the scientific report 2015

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Database coverage:
; Current Contents - Life Sciences ; Current Contents - Physical, Chemical and Earth Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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