Journal Article

FZJ-2015-05075

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Functional effects of distinct innervation styles of pyramidal cells by fast spiking cortical interneurons

Kubota, Y. (Corresponding author) ; Kondo, S. ; Nomura, M. ; Hatada, S. ; Yamaguchi, N. ; Mohamed, A. A. ; Karube, F. ; Lübke, J.FZJ* ; Kawaguchi, Y.

2015
eLife Sciences Publications Cambridge

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Please use a persistent id in citations: http://hdl.handle.net/2128/9015  doi:10.7554/eLife.07919

Abstract: Inhibitory interneurons target precise membrane regions on pyramidal cells, but differences in their functional effects on somata, dendrites and spines remain unclear. We analyzed inhibitory synaptic events induced by cortical, fast-spiking (FS) basket cells which innervate dendritic shafts and spines as well as pyramidal cell somata. Serial electron micrographs (EMgs) reconstruction showed that somatic synapses were larger than dendritic contacts. Simulations with precise anatomical and physiological data reveal functional differences between different innervation styles. FS cell soma-targeting synapses initiate a strong, global inhibition, those on shafts inhibit more restricted dendritic zones, while synapses on spines may mediate a strictly local veto. Thus, FS cell synapses of different sizes and sites provide functionally diverse forms of pyramidal cell inhibition.

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Contributing Institute(s):

1. Molekulare Organisation des Gehirns (INM-2)

Research Program(s):

1. 571 - Connectivity and Activity (POF3-571) (POF3-571)

Appears in the scientific report 2015

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Database coverage:
; ; ; ; BIOSIS Previews ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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