Deep brain stimulation and cognitive decline in Parkinson’s disease: The predictive value of electroencephalography

Markser, A.; Fink, Gereon Rudolf; Lewis, C. J.; Dembek, T. A.; Eggers, C.; Maier, F.; Timmermann, L.; Burghaus, L.; Kalbe, E.; Pedrosa, D.

doi:10.1007/s00415-015-7839-8

Journal Article

FZJ-2015-05204

Deep brain stimulation and cognitive decline in Parkinson’s disease: The predictive value of electroencephalography

Markser, A. ; Maier, F. (Corresponding author) ; Lewis, C. J. ; Dembek, T. A. ; Pedrosa, D. ; Eggers, C. ; Timmermann, L. ; Kalbe, E. ; Fink, G. R.FZJ* ; Burghaus, L.

2015
Steinkopff [Darmstadt]

Journal of neurology 262(10), 2275-2284 (2015) [10.1007/s00415-015-7839-8]

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Please use a persistent id in citations: doi:10.1007/s00415-015-7839-8

Abstract: Some Parkinson’s disease (PD) patients treated with subthalamic nucleus deep brain stimulation (STN-DBS) develop new-onset cognitive decline. We examined whether clinical EEG recordings can be used to predict cognitive deterioration in PD patients undergoing STN-DBS. In this retrospective study, we used the Grand Total EEG (GTE)-score (short and total) to evaluate pre- and postoperative EEGs. In PD patients undergoing STN-DBS (N = 30), cognitive functioning was measured using Mini-Mental State Test and DemTect before and after surgery. Severity of motor impairment was assessed using the Unified Parkinson’s Disease Rating Scale-III. Patients were classified into patients with or without cognitive decline after STN-DBS surgery. Epidemiological data, pre- and postoperative EEG recordings as well as neuropsychological and neurological data, electrode positions and the third ventricle width were compared. A logistic regression model was used to identify predictors of cognitive decline. Motor deficits significantly improved from pre- to post-surgery, while the mean GTE-scores increased significantly. Six patients developed cognitive deterioration 4–12 months postoperatively. These patients had significantly higher preoperative GTE-scores than patients without cognitive deterioration, although preoperative cognitive functioning was comparable. Electrode positions, brain atrophy and neurological data did not differ between groups. Logistic regression analysis identified the GTE-score as a significant predictor of postoperative cognitive deterioration. Data suggest that the preoperative GTE-score can be used to identify PD patients that are at high risk for developing cognitive deterioration after STN-DBS surgery even though their preoperative cognitive state was normal.

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