Journal Article

FZJ-2015-07695

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Unusual Dynamics of Concentration Fluctuations in Solutions of Weakly Attractive Globular Proteins

Bucciarelli, S. ; Casal-Dujat, L. ; De Michele, C. ; Sciortino, F. ; Dhont, J. K. G.FZJ* ; Bergenholtz, J. ; Farago, B. ; Schurtenberger, P. ; Stradner, A. (Corresponding author)

2015
ACS Washington, DC

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Please use a persistent id in citations: http://hdl.handle.net/2128/9597  doi:10.1021/acs.jpclett.5b02092

Abstract: The globular protein γB-crystallin exhibits a complex phase behavior, where liquid–liquid phase separation characterized by a critical volume fraction ϕc = 0.154 and a critical temperature Tc = 291.8 K coexists with dynamical arrest on all length scales at volume fractions around ϕ ≈ 0.3–0.35, and an arrest line that extends well into the unstable region below the spinodal. However, although the static properties such as the osmotic compressibility and the static correlation length are in quantitative agreement with predictions for binary liquid mixtures, this is not the case for the dynamics of concentration fluctuations described by the dynamic structure factor S(q,t). Using a combination of dynamic light scattering and neutron spin echo measurements, we demonstrate that the competition between critical slowing down and dynamical arrest results in a much more complex wave vector dependence of S(q,t) than previously anticipated.

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Contributing Institute(s):

1. Weiche Materie (ICS-3)

Research Program(s):

1. 551 - Functional Macromolecules and Complexes (POF3-551) (POF3-551)

Appears in the scientific report 2015

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Database coverage:
; ; Current Contents - Physical, Chemical and Earth Sciences ; Free to read ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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