Journal Article

FZJ-2016-00528

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The mammalian autophagy initiator complex contains 2 HORMA domain proteins.

Michel, M. ; Schwarten, M.FZJ* ; Decker, C. ; Nagel-Steger, L.FZJ* ; Willbold, D.FZJ* ; Weiergräber, O. H. (Corresponding author)FZJ*

2015
Taylor & Francis Abingdon, Oxon

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Please use a persistent id in citations: doi:10.1080/15548627.2015.1076605

Abstract: ATG101 is an essential component of the ULK complex responsible for initiating cellular autophagy in mammalian cells; its 3-dimensional structure and molecular function, however, are currently unclear. Here we present the X-ray structure of human ATG101. The protein displays an open HORMA domain fold. Both structural properties and biophysical evidence indicate that ATG101 is locked in this conformation, in contrast to the prototypical HORMA domain protein MAD2. Moreover, we discuss a potential mode of dimerization with ATG13 as a fundamental aspect of ATG101 function.

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Contributing Institute(s):

1. Strukturbiochemie (ICS-6)

Research Program(s):

1. 552 - Engineering Cell Function (POF3-552) (POF3-552)

Appears in the scientific report 2015

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Database coverage:
; BIOSIS Previews ; IF >= 10 ; JCR ; NCBI Molecular Biology Database ; No Authors Fulltext ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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