Journal Article

PreJuSER-5684

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Budding and vesiculation induced by conical membrane inclusions

Auth, T.FZJ* ; Gompper, G.FZJ*

2009
APS College Park, Md.

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Please use a persistent id in citations: http://hdl.handle.net/2128/9324  doi:10.1103/PhysRevE.80.031901

Abstract: Conical inclusions in a lipid bilayer generate an overall spontaneous curvature of the membrane that depends on concentration and geometry of the inclusions. Examples are integral and attached membrane proteins, viruses, and lipid domains. We propose an analytical model to study budding and vesiculation of the lipid bilayer membrane, which is based on the membrane bending energy and the translational entropy of the inclusions. If the inclusions are placed on a membrane with similar curvature radius, their repulsive membrane-mediated interaction is screened. Therefore, for high inclusion density the inclusions aggregate, induce bud formation, and finally vesiculation. Already with the bending energy alone our model allows the prediction of bud radii. However, in case the inclusions induce a single large vesicle to split into two smaller vesicles, bending energy alone predicts that the smaller vesicles have different sizes whereas the translational entropy favors the formation of equal-sized vesicles. Our results agree well with those of recent computer simulations.

Keyword(s): J

Note: Record converted from VDB: 12.11.2012

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Contributing Institute(s):

1. Theorie der Weichen Materie und Biophysik (IFF-2)
2. Theorie der Weichen Materie und Biophysik (IAS-2)
3. Jülich Aachen Research Alliance - High-Performance Computing (JARA-HPC)

Research Program(s):

1. Kondensierte Materie (P54)

Appears in the scientific report 2009

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Database coverage:
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