Journal Article

PreJuSER-57200

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Magnetic particle detection by frequency mixing for immunoassay applications

Krause, H.-J.FZJ* ; Wolters, N.FZJ* ; Zhang, Y.FZJ* ; Offenhäusser, A.FZJ* ; Miethe, P. ; Meyer, M. H. F. ; Hartmann, M. ; Keusgen, M.

2007
North-Holland Publ. Co. Amsterdam

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Please use a persistent id in citations: doi:10.1016/j.jmmm.2006.10.1164

Abstract: For magnetic immunoassay applications, a novel magnetic reader for quantification of magnetic particle concentrations has been developed. Upon magnetic excitation at two distinct frequencies incident on the sample, the response signal generated at a sum frequency is detected. The low-frequency field component periodically drives the magnetic particles into saturation, which is probed by the high-frequency field. The appearance of frequency mixing lines is highly specific to the nonlinearity of the superparamagnetic particles' magnetization. The optimization of field coils, differential pickup coil, preamplifier, demodulators and filters are discussed. The output signal is linear for four orders of magnitude in iron concentration. (C) 2006 Elsevier B.V. All rights reserved.

Keyword(s): J ; magnetic detection (auto) ; frequency mixing (auto) ; superparamagnetism (auto) ; nonlinearity (auto) ; induction coil (auto) ; immunoassay (auto)

Note: Record converted from VDB: 12.11.2012

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Contributing Institute(s):

1. Bioelektronik (IBN-2)
2. Center of Nanoelectronic Systems for Information Technology (CNI)
3. Jülich-Aachen Research Alliance - Fundamentals of Future Information Technology (JARA-FIT)

Research Program(s):

1. Grundlagen für zukünftige Informationstechnologien (P42)

Appears in the scientific report 2007

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