Journal Article

PreJuSER-59134

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Investigation of Interaction of Dimethylsulfoxide with Lipid Membranes via Small-Angle Neutron Scattering

Gorshkova, Y.FZJ* ; Gordeliy, V. I.FZJ*

2007
MAIK "Nauka/Interperiodica" Woodbury, NY

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Please use a persistent id in citations: doi:10.1134/S1063774507030364

Abstract: The influence of dimethyl sulfoxide (CH3)(2)SO (DMSO) on the structure of membranes of 1,2-dimiristoyl-sn-glycero-3-phosphatidylcholine (DMPC) in an excess of a water-DMSO solvent is investigated over a wide range of DMSO molar concentrations 0.0 <= X-DMSO <= 1.0 at temperatures T = 12.5 and 55 degrees C. The dependences of the repeat distance d of multilamellar membranes and the thickness d(b) of single vesicles on the molar concentration X-DMSO in the L-beta. gel and L-alpha liquid-crystalline phases are determined by small-angle neutron scattering. The intermembrane distance, is determined from the repeat distance d and the membrane thickness d(b). It is shown that an increase in the molar concentration X-DMSO leads to a considerable decrease in the intermembrane distance and that, at X-DMSO = 0.4, the neighboring membranes are virtually in steric contact with each other. The use of the deuterated phospholipid (DMSO-D6) and the contrast variation method makes it possible, for the first time, to determine the number of DMSO molecules strongly bound to the membrane.

Keyword(s): J

Note: Record converted from VDB: 12.11.2012

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Contributing Institute(s):

1. Molekulare Biophysik (INB-2)

Research Program(s):

1. Funktion und Dysfunktion des Nervensystems (P33)

Appears in the scientific report 2007

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