Journal Article

FZJ-2016-02764

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Different involvement of subregions within dorsal premotor and medial frontal cortex for pro- and antisaccades.

Cieslik, E. (Corresponding author)FZJ* ; Seidler, I. ; Laird, A. R. ; Fox, P. T. ; Eickhoff, S.FZJ*

2016
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.neubiorev.2016.05.012

Abstract: The antisaccade task has been widely used to investigate cognitive action control. While the general network for saccadic eye movements is well defined, the exact location of eye fields within the frontal cortex strongly varies between studies. It is unknown whether this inconsistency reflects spatial uncertainty or is the result of different involvement of subregions for specific aspects of eye movement control. The aim of the present study was to examine functional differentiations within the frontal cortex by integrating results from neuroimaging studies analyzing pro- and antisaccade behavior using meta-analyses. The results provide evidence for a differential functional specialization of neighboring oculomotor frontal regions, with lateral frontal eye fields (FEF) and supplementary eye field (SEF) more often involved in prosaccades while medial FEF and anterior midcingulate cortex (aMCC) revealed consistent stronger involvement for antisaccades. This dissociation was furthermore mirrored by functional connectivity analyses showing that the lateral FEF and SEF are embedded in a motor output network, while medial FEF and aMCC are integrated in a multiple demand network.

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Contributing Institute(s):

1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)

Research Program(s):

1. 571 - Connectivity and Activity (POF3-571) (POF3-571)
2. HBP - The Human Brain Project (604102) (604102)

Appears in the scientific report 2016

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Current Contents - Life Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; No Authors Fulltext ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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