Journal Article

FZJ-2016-04201

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Interface dynamics of competing tissues

Podewitz, N. ; Jülicher, F. ; Gompper, G.FZJ* ; Elgeti, J. (Corresponding author)FZJ*

2016
Dt. Physikalische Ges. [Bad Honnef]

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Please use a persistent id in citations: http://hdl.handle.net/2128/12143  doi:10.1088/1367-2630/18/8/083020

Abstract: Tissues can be characterized by their homeostatic stress, i.e. the value of stress for which cell division and cell death balance. When two different tissues grow in competition, a difference of their homeostatic stresses determines which tissue grows at the expense of the second. This then leads to the propagation of the interface separating the tissues. Here, we study structural and dynamical properties of this interface by combining continuum theory with mesoscopic simulations of a cell-based model. Using a simulation box that moves with the interface, we find that a stationary state exists in which the interface has a finite width and propagates with a constant velocity. The propagation velocity in the simulations depends linearly on the homeostatic stress difference, in excellent agreement with the analytical predictions. This agreement is also seen for the stress and velocity profiles. Finally, we analyzed the interface growth and roughness as a function of time and system size. We estimated growth and roughness exponents, which differ from those previously obtained for simple tissue growth

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Contributing Institute(s):

1. Theorie der Weichen Materie und Biophysik (ICS-2)

Research Program(s):

1. 553 - Physical Basis of Diseases (POF3-553) (POF3-553)

Appears in the scientific report 2016

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Database coverage:
; ; ; ; Current Contents - Physical, Chemical and Earth Sciences ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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