Journal Article

FZJ-2016-05391

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Ircinal E, a New Manzamine Derivative frim the Indonesian Marine Sponge Acanthostrongylophora ingens

AlTarabeen, M. ; Daletos, G. ; Ebrahim, W. ; Müller, W. E. G. ; Hartmann, R.FZJ* ; Lin, W. ; Proksch, P. (Corresponding author)

2015
NPC Westerville, Ohio

Abstract: Chemical investigation of the MeOH extract of the sponge Acanthostrongylophora ingens afforded the new manzamine derivative ircinal E (1), in addition tosix known metabolites (2–7). The structure of the new compound was unequivocally elucidated using one- and two-dimensional NMR spectroscopy, as wellas high-resolution mass spectrometry. Compounds 1–6 exhibited strong to moderate cytotoxicity against the murine lymphoma L5178Y cell line with IC50values ranging from 2.8 to 21.7 μM.

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Contributing Institute(s):

1. Strukturbiochemie (ICS-6)

Research Program(s):

1. 552 - Engineering Cell Function (POF3-552) (POF3-552)

Appears in the scientific report 2016

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Database coverage:
; Current Contents - Agriculture, Biology and Environmental Sciences ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; No Authors Fulltext ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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