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| Hauptseite > Publikationsdatenbank > Elevated Cytosolic Cl − Concentrations in Dendritic Knobs of Mouse Vomeronasal Sensory Neurons |
| Hauptseite > Publikationsdatenbank > Elevated Cytosolic Cl − Concentrations in Dendritic Knobs of Mouse Vomeronasal Sensory Neurons |
| Journal Article | FZJ-2016-07438 |
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2016
Oxford Univ. Press
Oxford
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Please use a persistent id in citations: doi:10.1093/chemse/bjw077
Abstract: In rodents, the vomeronasal system controls social and sexual behavior. However, several mechanistic aspects of sensory signaling in the vomeronasal organ remain unclear. Here, we investigate the biophysical basis of a recently proposed vomeronasal signal transduction component—a Ca 2+ -activated Cl − current. As the physiological role of such a current is a direct function of the Cl − equilibrium potential, we determined the intracellular Cl − concentration in dendritic knobs of vomeronasal neurons. Quantitative fluorescence lifetime imaging of a Cl − -sensitive dye at the apical surface of the intact vomeronasal neuroepithelium revealed increased cytosolic Cl − levels in dendritic knobs, a substantially lower Cl − concentration in vomeronasal sustentacular cells, and an apparent Cl − gradient in vomeronasal neurons along their dendritic apicobasal axis. Together, our data provide a biophysical basis for sensory signal amplification in vomeronasal neuron microvilli by opening Ca 2+ -activated Cl − channels.
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