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| Home > Publications database > Amyloid deposition in younger adults is linked to episodic memory performance |
| Journal Article | FZJ-2016-07683 |
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2016
Wolters Kluwer
Philadelphia, Pa.
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Please use a persistent id in citations: doi:10.1212/WNL.0000000000003425
Abstract: Objective: To examine the relationship of β-amyloid (Aβ) deposition to episodic memory in younger (30–49 years), middle-older (50–69 years), and older adults (70–89 years). We hypothesized that subclinical levels of amyloid would be linked to memory in adults across the lifespan in a dose-dependent fashion. Of great interest was whether, within the younger group, a relationship between amyloid level and memory performance could be established.Methods: A total of 147 participants from the Dallas Lifespan Brain Study, aged 30–89, underwent PET imaging with 18F-florbetapir and cognitive assessment. We assessed the relationship between age group and amyloid and tested whether Aβ differentially affected memory performance across the 3 age groups.Results: We report a significant association of age to amyloid burden for younger and middle-older adults (r = 0.57 and 0.28, respectively), but not for the oldest group, although absolute level of amyloid increased across the age groups. Importantly, the youngest group showed a significant decrease in recall (r = −0.47, p = 0.004) and recognition memory (r = −0.48, p = 0.003) as a function of increases in Aβ burden, whereas this relationship was absent in the middle-older and oldest group (all p > 0.23).Conclusions: These results indicate that variance in subclinical levels of Aβ in younger adults is meaningful, and suggest that higher SUVRs relative to one's peers at a younger age is not entirely benign.
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