Journal Article

FZJ-2017-00122

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Comment on Hatzoglou et al: Dynamic contrast-enhanced MRI perfusion versus $^{18}$ FDG PET/CT in differentiating brain tumor progression from radiation injury

Cicone, F. (Corresponding author) ; Galldiks, N.FZJ* ; Minniti, G. ; Filss, C.FZJ* ; Scopinaro, F. ; Prior, J. O. ; Albert, N. L. ; Langen, K.-J.FZJ*

2017
Oxford Univ. Press Oxford

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Please use a persistent id in citations: doi:10.1093/neuonc/now283

Abstract: We read with great interest the paper by Hatzoglou et al, recently published in Neuro-Oncology,1 concerning the discrimination between progressive disease and radiotherapy-induced changes in brain tumors, which is a clinical challenge of paramount importance. To address this diagnostic problem, the authors compared dynamic contrast enhanced (DCE) MRI and fluorine-18-fluorodeoxyglucose (FDG) PET/CT in a total of 53 patients with primary brain tumors (n = 29) or brain metastases (n = 26). They found that the DCE MRI–derived plasma volume ratio (Vpratio) and transfer coefficient ratio (Ktransratio), as well as the FDG PET–derived standardized uptake value ratio (SUVratio) were useful in distinguishing between progression and radiation injury, both in the overall cohort and in the 2 main subgroups (primary and secondary brain tumors). They concluded, however, that DCE MRI–derived Vpratio was the “most robust” predictor of progression after showing a trend toward higher performances for Vpratio with respect to SUVratio (sensitivity and specificity = 92% and 77% vs 68% and 82%; AUC = 0.87 vs 0.75, P = .061, for Vpratio and SUVratio, respectively).

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)
2. Physik der Medizinischen Bildgebung (INM-4)
3. JARA-BRAIN (JARA-BRAIN)

Research Program(s):

1. 573 - Neuroimaging (POF3-573) (POF3-573)

Appears in the scientific report 2017

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Database coverage:
; Allianz-Lizenz / DFG ; Current Contents - Clinical Medicine ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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