Journal Article

FZJ-2017-03304

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Synaptic patterning and the timescales of cortical dynamics

Duarte, R. (Corresponding author)FZJ* ; Seeholzer, A. ; Zilles, K.FZJ* ; Morrison, A.FZJ*

2017
Current Biology Philadelphia, Pa.

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Please use a persistent id in citations: http://hdl.handle.net/2128/14303  doi:10.1016/j.conb.2017.02.007

Abstract: Neocortical circuits, as large heterogeneous recurrent networks, can potentially operate and process signals at multiple timescales, but appear to be differentially tuned to operate within certain temporal receptive windows. The modular and hierarchical organization of this selectivity mirrors anatomical and physiological relations throughout the cortex and is likely determined by the regional electrochemical composition. Being consistently patterned and actively regulated, the expression of molecules involved in synaptic transmission constitutes the most significant source of laminar and regional variability. Due to their complex kinetics and adaptability, synapses form a natural primary candidate underlying this regional temporal selectivity. The ability of cortical networks to reflect the temporal structure of the sensory environment can thus be regulated by evolutionary and experience-dependent processes.

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Contributing Institute(s):

1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)
2. JARA-BRAIN (JARA-BRAIN)
3. Computational and Systems Neuroscience (INM-6)

Research Program(s):

1. 571 - Connectivity and Activity (POF3-571) (POF3-571)
2. SMHB - Supercomputing and Modelling for the Human Brain (HGF-SMHB-2013-2017) (HGF-SMHB-2013-2017)
3. HBP SGA1 - Human Brain Project Specific Grant Agreement 1 (720270) (720270)

Appears in the scientific report 2017

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Database coverage:
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