Journal Article

FZJ-2017-03978

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Diattenuation of Brain Tissue and its Impact on 3D Polarized Light Imaging

Menzel, M. (Corresponding author)FZJ* ; Reckfort, J.FZJ* ; Weigand, D. ; Köse, H. ; Amunts, K.FZJ* ; Axer, M.FZJ*

2017
OSA Washington, DC

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Please use a persistent id in citations: http://hdl.handle.net/2128/14808  doi:10.1364/BOE.8.003163

Abstract: 3D-polarized light imaging (3D-PLI) reconstructs nerve fibers in histological brain sections by measuring their birefringence. This study investigates another effect caused by the optical anisotropy of brain tissue – diattenuation. Based on numerical and experimental studies and a complete analytical description of the optical system, the diattenuation was determined to be below 4 % in rat brain tissue. It was demonstrated that the diattenuation effect has negligible impact on the fiber orientations derived by 3D-PLI. The diattenuation signal, however, was found to highlight different anatomical structures that cannot be distinguished with current imaging techniques, which makes Diattenuation Imaging a promising extension to 3D-PLI.

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Contributing Institute(s):

1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)

Research Program(s):

1. 571 - Connectivity and Activity (POF3-571) (POF3-571)
2. SMHB - Supercomputing and Modelling for the Human Brain (HGF-SMHB-2013-2017) (HGF-SMHB-2013-2017)
3. HBP SGA1 - Human Brain Project Specific Grant Agreement 1 (720270) (720270)

Appears in the scientific report 2017

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Database coverage:
; ; ; Current Contents - Engineering, Computing and Technology ; DOAJ Seal ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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