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| Hauptseite > Publikationsdatenbank > Neocortical electrical stimulation for epilepsy: Closed-loop versus open-loop |
| Hauptseite > Publikationsdatenbank > Neocortical electrical stimulation for epilepsy: Closed-loop versus open-loop |
| Journal Article | FZJ-2018-02171 |
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2018
Elsevier89326
Amsterdam [u.a.]
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Please use a persistent id in citations: http://hdl.handle.net/2128/21401 doi:10.1016/j.eplepsyres.2018.02.010
Abstract: The aim of this review is to evaluate whether open-loop or closed-loop neocortical electrical stimulation should be the preferred approach to manage seizures in intractable epilepsy.Twenty cases of open-loop neocortical stimulation with an implanted device have been reported, in 5 case studies. Closed-loop stimulation with an implanted device has been investigated in a larger number of patients in the RNS System clinical trials. With 230 patients enrolled at the start of the Long-term Treatment Trial, 115 remained at the last reported follow-up. Open-loop stimulation reduced seizure frequency in patients on average with over 90% compared to baseline. Closed-loop stimulation reduces seizure frequency with 60%–65%.Even though open-loop neocortical electrical stimulation has only been reported in 20 patients, and closed-loop in much a larger sample, evidence suggests that both approaches are effective in reducing seizures. It remains an open question which should be clinically preferred. Therefore, a head-to-head adaptive clinical study comparing both approaches is proposed
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