Action and semantic tool knowledge - Effective connectivity in the underlying neural networks

Kleineberg, Nina; Binder, Ellen; Weiss, Peter H.; Dovern, Anna; Grefkes, Christian; Eickhoff, Simon; Fink, Gereon R.

doi:10.1002/hbm.24188

Journal Article

FZJ-2018-02697

Action and semantic tool knowledge - Effective connectivity in the underlying neural networks

Kleineberg, N.FZJ* ; Dovern, A. ; Binder, E. ; Grefkes, C.FZJ* ; Eickhoff, S.FZJ* ; Fink, G. R.FZJ* ; Weiss, P. H. (Corresponding author)

2018
Wiley-Liss New York, NY

Human brain mapping 39(9), 3473-3486 (2018) [10.1002/hbm.24188]

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Please use a persistent id in citations: http://hdl.handle.net/2128/21080 doi:10.1002/hbm.24188

Abstract: Evidence from neuropsychological and imaging studies indicate that action and semantic knowledge about tools draw upon distinct neural substrates, but little is known about the underlying interregional effective connectivity. With fMRI and dynamic causal modeling (DCM) we investigated effective connectivity in the left‐hemisphere (LH) while subjects performed (i) a function knowledge and (ii) a value knowledge task, both addressing semantic tool knowledge, and (iii) a manipulation (action) knowledge task. Overall, the results indicate crosstalk between action nodes and semantic nodes. Interestingly, effective connectivity was weakened between semantic nodes and action nodes during the manipulation task. Furthermore, pronounced modulations of effective connectivity within the fronto‐parietal action system of the LH (comprising lateral occipito‐temporal cortex, intraparietal sulcus, supramarginal gyrus, inferior frontal gyrus) were observed in a bidirectional manner during the processing of action knowledge. In contrast, the function and value knowledge tasks resulted in a significant strengthening of the effective connectivity between visual cortex and fusiform gyrus. Importantly, this modulation was present in both semantic tasks, indicating that processing different aspects of semantic knowledge about tools evokes similar effective connectivity patterns. Data revealed that interregional effective connectivity during the processing of tool knowledge occurred in a bidirectional manner with a weakening of connectivity between areas engaged in action and semantic knowledge about tools during the processing of action knowledge. Moreover, different semantic tool knowledge tasks elicited similar effective connectivity patterns.

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ddc:610

Note: Funding information Medical Faculty, University of Cologne, Grant/Award Number: 3615/0129/31; Marga‐ and Walter‐Boll Stiftung; Helmholtz Portfolio Theme “Supercomputing and Modeling for the Human Brain”; University of Cologne Emerging Groups Initiative (CONNECT group) implemented into the Institutional Strategy of the University of Cologne and the German Excellence Initiative

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