Journal Article

FZJ-2018-02932

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Towards a human self-regulation system: Common and distinct neural signatures of emotional and behavioural control

Langner, R. (Corresponding author)FZJ* ; Leiberg, S. ; Hoffstaedter, F.FZJ* ; Eickhoff, S.FZJ*

2018
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: http://hdl.handle.net/2128/18628  doi:10.1016/j.neubiorev.2018.04.022

Abstract: Self-regulation refers to controlling our emotions and actions in the pursuit of higher-order goals. Although research suggests commonalities in the cognitive control of emotion and action, evidence for a shared neural substrate is scant and largely circumstantial. Here we report on two large-scale meta-analyses of human neuroimaging studies on emotion or action control, yielding two fronto-parieto-insular networks. The networks' overlap, however, was restricted to four brain regions: posteromedial prefrontal cortex, bilateral anterior insula, and right temporo-parietal junction. Conversely, meta-analytic contrasts revealed major between-network differences, which were independently corroborated by clustering domain-specific regions based on their intrinsic functional connectivity, as well as by functionally characterizing network sub-clusters using the BrainMap database for quantitative forward and reverse inference. Collectively, our analyses identified a core system for implementing self-control across emotion and action, beyond which, however, either regulation facet appears to rely on broadly similar yet distinct subnetworks. These insights into the neurocircuitry subserving affective and executive facets of self-control suggest both processing commonalities and differences between the two aspects of human self-regulation.

Note: This work was supported by the Deutsche Forschungsgemeinschaft (LA 3071/3-1, EI 816/4-1); the National Institute of Mental Health (R01-MH074457); the Helmholtz Portfolio Theme “Supercomputing and Modeling for the Human Brain”; and the European Union Seventh Framework Programme (grant agreement no. 604102).

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Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)

Research Program(s):

1. 571 - Connectivity and Activity (POF3-571) (POF3-571)
2. HBP - The Human Brain Project (604102) (604102)

Appears in the scientific report 2018

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Database coverage:
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