Journal Article

FZJ-2018-03236

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Differential Resting-State Connectivity Patterns of the Right Anterior and Posterior Dorsolateral Prefrontal Cortices (DLPFC) in Schizophrenia

Chechko, N. (Corresponding author) ; Cieslik, E.FZJ* ; Müller, V.FZJ* ; Nickl-Jockschat, T. ; Derntl, B. ; Kogler, L. ; Aleman, A. ; Jardri, R. ; Sommer, I. E. ; Gruber, O. ; Eickhoff, S.FZJ*

2018
Frontiers Research Foundation Lausanne

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Please use a persistent id in citations: http://hdl.handle.net/2128/18730  doi:10.3389/fpsyt.2018.00211

Abstract: In schizophrenia (SCZ), dysfunction of the dorsolateral prefrontal cortex (DLPFC) has been linked to the deficits in executive functions and attention. It has been suggested that, instead of considering the right DLPFC as a cohesive functional entity, it can be divided into two parts (anterior and posterior) based on its whole-brain connectivity patterns. Given these two subregions' differential association with cognitive processes, we investigated the functional connectivity (FC) profile of both subregions through resting-state data to determine whether they are differentially affected in SCZ. Resting-state magnetic resonance imaging (MRI) scans were obtained from 120 patients and 172 healthy controls (HC) at 6 different MRI sites. The results showed differential FC patterns for the anterior and posterior parts of the right executive control-related DLPFC in SCZ with the parietal, the temporal and the cerebellar regions, along with a convergent reduction of connectivity with the striatum and the occipital cortex. An increased psychopathology level was linked to a higher difference in posterior vs. anterior FC for the left IFG/anterior insula, regions involved in higher-order cognitive processes. In sum, the current analysis demonstrated that even between two neighboring clusters connectivity could be differentially disrupted in SCZ. Lacking the necessary anatomical specificity, such notions may in fact be detrimental to a proper understanding of SCZ pathophysiology.

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Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)

Research Program(s):

1. 572 - (Dys-)function and Plasticity (POF3-572) (POF3-572)
2. KFO 241 - Genotyp-Phänotypbeziehungen und Neurobiologie des longitudinalen Psychoseverlaufs (160201488) (160201488)

Appears in the scientific report 2018

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Database coverage:
; ; ; ; DOAJ Seal ; Emerging Sources Citation Index ; SCOPUS ; Thomson Reuters Master Journal List ; Web of Science Core Collection

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