Human Pregenual Anterior Cingulate Cortex: Structural, Functional, and Connectional Heterogeneity

Palomero-Gallagher, Nicola; Mohlberg, Hartmut; Amunts, Katrin; Hoffstaedter, Felix; Eickhoff, Simon; Zilles, Karl

doi:10.1093/cercor/bhy124

Journal Article

FZJ-2018-03306

Human Pregenual Anterior Cingulate Cortex: Structural, Functional, and Connectional Heterogeneity

Palomero-Gallagher, N. (Corresponding author)FZJ* ; Hoffstaedter, F.FZJ* ; Mohlberg, H.FZJ* ; Eickhoff, S.FZJ* ; Amunts, K.FZJ* ; Zilles, K.FZJ*

2018
Oxford Univ. Press Oxford

Cerebral cortex 29(6), 2552-2574 (2018) [10.1093/cercor/bhy124]

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Please use a persistent id in citations: http://hdl.handle.net/2128/22658 doi:10.1093/cercor/bhy124

Abstract: The human pregenual anterior cingulate cortex (pACC) encompasses 7 distinct cyto- and receptorarchitectonic areas. We lack a detailed understanding of the functions in which they are involved, and stereotaxic maps are not available. We present an integrated structural/functional map of pACC based on probabilistic cytoarchitectonic mapping and meta-analytic connectivity modeling and quantitative functional decoding. Due to the restricted spatial resolution of functional imaging data relative to the microstructural parcellation, areas p24a of the callosal sulcus and p24b on the surface of the cingulate gyrus were merged into a "gyral component" (p24ab) of area p24, and areas pv24c, pd24cv, and pd24cd, located within the cingulate sulcus were merged into a "sulcal component" (p24c) for meta-analytic analysis. Area p24ab was specifically associated with interoception, p24c with the inhibition of action, and p32, which was also activated by emotion induction tasks pertaining negatively valenced stimuli, with the ability to experience empathy. Thus, area p32 could be classified as cingulate association cortex playing a crucial role in the cognitive regulation of emotion. By this spectrum of functions, pACC is a structurally and functionally heterogeneous region, clearly differing from other parts of the anterior and middle cingulate cortex.

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ddc:610

Note: This study was partially supported by the European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreement No. 785907 (HBP SGA2), the National Institute of Mental Health (R01-MH074457), and the Helmholtz Portfolio Theme “Supercomputing and Modeling for the Human Brain.”

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Appears in the scientific report 2018

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