Journal Article

FZJ-2019-00092

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Chronology of motor-mediated microtubule streaming

Ravichandran, A.FZJ* ; Duman, Ö.FZJ* ; Hoore, M.FZJ* ; Saggiorato, G. ; Vliegenthart, G. A. (Corresponding author)FZJ* ; Auth, T. (Corresponding author)FZJ* ; Gompper, G. (Corresponding author)FZJ*

2019
eLife Sciences Publications Cambridge

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Please use a persistent id in citations: http://hdl.handle.net/2128/21502  doi:10.7554/eLife.39694

Abstract: We introduce a computer-based simulation model for coarse-grained, effective motor-mediated interaction between microtubule pairs to study the time-scales that compose cytoplasmic streaming. We characterise microtubule dynamics in two-dimensional systems by chronologically arranging five distinct processes of varying duration that make up streaming, from microtubule pairs to collective dynamics. The structures found were polarity sorted due to the propulsion of antialigned microtubules. This also gave rise to the formation of large polar-aligned domains, and streaming at the domain boundaries. Correlation functions, mean squared displacements, and velocity distributions reveal a cascade of processes ultimately leading to microtubule streaming and advection, spanning multiple microtubule lengths. The characteristic times for the processes span over three orders of magnitude from fast single-microtubule processes to slow collective processes. Our approach can be used to directly test the importance of molecular components, such as motors and crosslinking proteins between microtubules, on the collective dynamics at cellular scale.

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Contributing Institute(s):

1. Theorie der Weichen Materie und Biophysik (ICS-2)
2. JARA - HPC (JARA-HPC)

Research Program(s):

1. 553 - Physical Basis of Diseases (POF3-553) (POF3-553)
2. Hydrodynamics of Active Biological Systems (jiff26_20110501) (jiff26_20110501)

Appears in the scientific report 2019

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Database coverage:
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