Journal Article

FZJ-2019-01952

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png What magnetic resonance imaging reveals – A systematic review of the relationship between type II diabetes and associated brain distortions of structure and cognitive functioning

Rosenberg, J. (Corresponding author)FZJ* ; Lechea, N.FZJ* ; Pentang, G. N.FZJ* ; Shah, N. J.FZJ*

2019
Academic Press Orlando, Fla.

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Please use a persistent id in citations: doi:10.1016/j.yfrne.2018.10.001

Abstract: Due to its increasing prevalence, Type 2 diabetes mellitus (T2DM) represents a major health challenge for modern society. Despite it being of fundamental interest, only a few MRI studies have conducted statistical analyses to draw scientifically valid conclusions about the complex interplay of T2DM and its associated clinical, structural, functional, metabolite, as well as cognitive distortions. Therefore, a systematic review of 68 manuscripts, following the PRISMA guidelines, was conducted. Notably, although the associations between imaging, clinical, and cognitive variables are not fully homogeneous, findings show a clear trend towards a link between altered brain structure and a decline in cognitive processing ability. The results of the review highlight the heterogeneity of the methods used across manuscripts in terms of assessed clinical variables, imaging, and data analysis methods. This is particularly significant as, if the subjects’ criteria are not carefully considered, results are easily prone to confounding factors.

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Contributing Institute(s):

1. Physik der Medizinischen Bildgebung (INM-4)
2. JARA-BRAIN (JARA-BRAIN)
3. Jara-Institut Quantum Information (INM-11)

Research Program(s):

1. 573 - Neuroimaging (POF3-573) (POF3-573)

Appears in the scientific report 2019

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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