Journal Article

FZJ-2019-02206

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Impulsive aggression and response inhibition in attention-deficit/hyperactivity disorder and disruptive behavioral disorders: Findings from a systematic review

Puiu, A. A. (Corresponding author) ; Wudarczyk, O. ; Goerlich, K. S. ; Votinov, M.FZJ* ; Herpertz-Dahlmann, B. ; Turetsky, B. ; Konrad, K.FZJ*

2018
Elsevier Science Amsterdam [u.a.]

This record in other databases:      

Please use a persistent id in citations: http://hdl.handle.net/2128/21925  doi:10.1016/j.neubiorev.2018.04.016

Abstract: BackgroundAlthough impulsive aggression (IA) and dysfunctional response inhibition (RI) are hallmarks of attention-deficit/hyperactivity disorder (ADHD) and disrupted behavioral disorders (DBDs), little is known about their shared and distinct deviant neural mechanisms.Aims and MethodsHere, we selectively reviewed s/fMRI ADHD and DBD studies to identify disorder-specific and shared IA and RI aberrant neural mechanisms.ResultsIn ADHD, deviant prefrontal and cingulate functional activity was associated with increased IA. Structural alterations were most pronounced in the cingulate cortex. Subjects with DBDs showed marked cortico-subcortical dysfunctions. ADHD and DBDs share similar cortico-limbic structural and functional alterations. RI deficits in ADHD highlighted hypoactivity in the dorso/ventro-lateral PFC, insula, and striatum, while the paralimbic system was primarily dysfunctional in DBDs. Across disorders, extensively altered cortico-limbic dysfunctions underlie IA, while RI was mostly associated with aberrant prefrontal activity.ConclusionControl network deficits were evidenced across clinical phenotypes in IA and RI. Dysfunctions at any level within these cortico-subcortical projections lead to deficient cognitive-affective control by ascribing emotional salience to otherwise irrelevant stimuli. The clinical implications of these findings are discussed

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Contributing Institute(s):

1. Jara-Institut Brain structure-function relationships (INM-10)
2. Jara-Institut Quantum Information (INM-11)

Research Program(s):

1. 572 - (Dys-)function and Plasticity (POF3-572) (POF3-572)

Appears in the scientific report 2019

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Database coverage:
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