Journal Article

FZJ-2019-03153

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Mechanics of tissue competition: Interfaces stabilize coexistence

Ganai, N. ; Büscher, T.FZJ* ; Elgeti, J. (Corresponding author)FZJ* ; Gompper, G.FZJ*

2019
IOP73379 [London]

This record in other databases:    

Please use a persistent id in citations: http://hdl.handle.net/2128/22298  doi:10.1088/1367-2630/ab2475

Abstract: Mechanical forces influence the dynamics of growing tissues. Computer simulations are employed to study the importance of interfacial effects in tissue competition. It was speculated previously that mechanical pressure determines the competition, where the determining quantity is the homeostatic pressure - the pressure where division and apoptosis balance; the tissue with the higher homeostatic pressure overwhelms the other. In contrast, we find that a weaker tissue can persist in stable coexistence with a stronger tissue, if adhesion between them is small enough. An analytic continuum description can quantitatively describe the underlying mechanism and reproduce the resulting pressures and cell-number fractions. Furthermore, simulations reveal a variety of coexisting structures, ranging from spherical inclusions to a bicontinuous state.

---

Contributing Institute(s):

1. Theorie der Weichen Materie und Biophysik (ICS-2)

Research Program(s):

1. 553 - Physical Basis of Diseases (POF3-553) (POF3-553)

Appears in the scientific report 2019

---

Database coverage:
; ; ; ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; DOAJ Seal ; Ebsco Academic Search ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

---