Progress Update from the Hippocampal Subfields Group

Olsen, R. K.; Schlichting, M. L.; Raz, N.; Yushkevich, P. A.; Burggren, A. C.; Mulligan, E. M.; Stark, C. E. L.; Amunts, Katrin; Daugherty, A. M.; Keresztes, A.; Werkle-Bergner, M.; Boccardi, M.; Kedo, Olga; DeKraker, J.; Mueller, S. G.; Amaral, R. S. C.; Bakker, A.; Palombo, D. J.; Insausti, R.; Carr, V. A.; Bocchetta, M.; Steve, T. A.; Chételat, G.; Suthana, N. A.; Kanel, P.; Augustinack, J. C.; Yu, Q.; Ofen, N.; Huang, Y.; Lindenberger, U.; Johnson, E. G.; Geerings, M. I.; Berron, D.; Pasquini, L.; Group, Hippocampal Subfields; Ding, S.-L.; Lee, J. K.; Bender, A. R.; Wisse, L. E. M.; Chakravarty, M. M.; Kennedy, K. M.; Wang, L.; Shing, Y. L.; La Joie, R.; Pluto, J.; Rodrigue, K. M.; de Flores, R.

doi:10.1016/j.dadm.2019.04.001

Journal Article

FZJ-2019-03167

Progress Update from the Hippocampal Subfields Group

Olsen, R. K. (Corresponding author) ; Carr, V. A. ; Daugherty, A. M. ; La Joie, R. ; Amaral, R. S. C. ; Amunts, K.FZJ* ; Augustinack, J. C. ; Bakker, A. ; Bender, A. R. ; Berron, D. ; Boccardi, M. ; Bocchetta, M. ; Burggren, A. C. ; Chakravarty, M. M. ; Chételat, G. ; de Flores, R. ; DeKraker, J. ; Ding, S.-L. ; Geerings, M. I. ; Huang, Y. ; Insausti, R. ; Johnson, E. G. ; Kanel, P. ; Kedo, O.FZJ* ; Kennedy, K. M. ; Keresztes, A. ; Lee, J. K. ; Lindenberger, U. ; Mueller, S. G. ; Mulligan, E. M. ; Ofen, N. ; Palombo, D. J. ; Pasquini, L. ; Pluto, J. ; Raz, N. ; Rodrigue, K. M. ; Schlichting, M. L. ; Shing, Y. L. ; Stark, C. E. L. ; Steve, T. A. ; Suthana, N. A. ; Wang, L. ; Werkle-Bergner, M. ; Yushkevich, P. A. ; Yu, Q. ; Wisse, L. E. M. ; Group, H. S. (Collaboration author)

2019
Elsevier Amsterdam [u.a.]

Alzheimer's & dementia / Diagnosis, assessment & disease monitoring 11, 439-449 (2019) [10.1016/j.dadm.2019.04.001]

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Please use a persistent id in citations: http://hdl.handle.net/2128/22397 doi:10.1016/j.dadm.2019.04.001

Abstract: IntroductionHeterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence.MethodsOur international working group, funded by the EU Joint Programme–Neurodegenerative Disease Research (JPND), is working toward the production of a reliable, validated, harmonized protocol for segmentation of medial temporal lobe regions. The working group uses a novel postmortem data set and online consensus procedures to ensure validity and facilitate adoption.ResultsThis progress report describes the initial results and milestones that we have achieved to date, including the development of a draft protocol and results from the initial reliability tests and consensus procedures.DiscussionA harmonized protocol will enable the standardization of segmentation methods across laboratories interested in medial temporal lobe research worldwide.

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