Journal Article

FZJ-2019-03622

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Deficient allo-centric visuospatial processing contributes to apraxic deficits in sub-acute right hemisphere stroke

Ubben, S. D.FZJ* ; Fink, G. R.FZJ* ; Kaesberg, S. ; Kalbe, E. ; Kessler, J. ; Vossel, S.FZJ* ; Weiss, P. H. (Corresponding author)FZJ*

2020
Wiley Hoboken, NJ [u.a.]

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Please use a persistent id in citations: http://hdl.handle.net/2128/24975  doi:10.1111/jnp.12191

Abstract: While visuospatial deficits are well‐characterized cognitive sequelae of right hemisphere (RH ) stroke, apraxic deficits in RH stroke remain poorly understood. Likewise, very little is known about the association between apraxic and visuospatial deficits in RH stroke or about the putative common or differential pathophysiology underlying these deficits. Therefore, we examined the behavioural and lesion patterns of apraxic deficits (pantomime of object use and bucco‐facial imitation) and visuospatial deficits (line bisection and letter cancellation tasks) in 50 sub‐acute RH stroke patients. Using principal component analysis (PCA ), we characterized the relationship between the two deficits. We hypothesized that any interaction of these neuropsychological measures may be influenced by the demands of ego‐centric/space‐based and/or allo‐centric/object‐based processing. Contralesional visuospatial deficits were common in our clinically representative patient sample, affecting more than half of RH stroke patients. Furthermore, about one‐third of all patients demonstrated apraxic deficits. PCA revealed that pantomiming and the imitation of bucco‐facial gestures loaded clearly on a first component (PCA 1), while letter cancellation loaded heavily on a second component (PCA 2). For line bisection, overall mean deviation loaded on PCA 1, while the difference between the mean deviations in contra‐ versus ipsilesional space loaded on PCA 2. These results suggest that PCA 1 represents allo‐centric/object‐based processing and PCA 2 ego‐centric/space‐based processing. This interpretation was corroborated by the statistical lesion analyses with the component scores. Data suggest that disturbed allo‐centric/object‐based processing contributes to apraxic pantomime and imitation deficits in (sub‐acute) RH stroke.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)

Research Program(s):

1. 572 - (Dys-)function and Plasticity (POF3-572) (POF3-572)

Appears in the scientific report 2020

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Database coverage:
; ; Clarivate Analytics Master Journal List ; Current Contents - Social and Behavioral Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Social Sciences Citation Index ; Web of Science Core Collection

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