Journal Article

FZJ-2019-04036

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png lMicrofluidic Particle Sorting in Concentrated Erythrocyte Suspensions

Holm, S. H. ; Zhang, Z. ; Beech, J. P. ; Gompper, G.FZJ* ; Fedosov, D. A. (Corresponding author)FZJ* ; Tegenfeldt, J. O.

2019
American Physical Society College Park, Md. [u.a.]

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Please use a persistent id in citations: http://hdl.handle.net/2128/22553  doi:10.1103/PhysRevApplied.12.014051

Abstract: An important step in diagnostics is the isolation of specific cells and microorganisms of interest from blood. Since such bioparticles are often present at very low concentrations, throughput needs to be as high as possible. In addition, to ensure simplicity, a minimum of sample preparation is important. Therefore, sorting schemes that function for whole blood are highly desirable. Deterministic lateral displacement (DLD) devices have proven to be very precise and versatile in terms of a wide range of sorting parameters. To better understand how DLD devices perform for blood as the hematocrit increases, we carry out measurements and simulations for spherical particles in the micrometer range which move through DLD arrays for different flow velocities and hematocrits ranging from pure buffer to concentrated erythrocyte suspensions mimicking whole blood. We find that the separation function of the DLD array is sustained even though the blood cells introduce a shift in the trajectories and a significant dispersion for particles whose diameters are close to the critical size in the device. Simulations qualitatively replicate our experimental observations and help us identify fundamental mechanisms for the effect of hematocrit on the performance of the DLD device

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Contributing Institute(s):

1. Theorie der Weichen Materie und Biophysik (ICS-2)
2. JARA - HPC (JARA-HPC)

Research Program(s):

1. 553 - Physical Basis of Diseases (POF3-553) (POF3-553)
2. Blood flow in microvascular networks (jics21_20181101) (jics21_20181101)

Appears in the scientific report 2019

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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