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| Hauptseite > Publikationsdatenbank > PSA and VIM DBS efficiency in essential tremor depends on distance to the dentatorubrothalamic tract |
| Hauptseite > Publikationsdatenbank > PSA and VIM DBS efficiency in essential tremor depends on distance to the dentatorubrothalamic tract |
| Journal Article | FZJ-2020-01627 |
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2020
Elsevier
[Amsterdam u.a.]
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Please use a persistent id in citations: http://hdl.handle.net/2128/24611 doi:10.1016/j.nicl.2020.102235
Abstract: ObjectiveTo investigate the relation between deep brain stimulation (DBS) of the posterior-subthalamic-area (PSA) and the ventral-intermediate-nucleus (VIM) and the distance to the dentatorubrothalamic tract (DRTT) in essential tremor (ET).MethodsTremor rating scale (TRS) hemi-scores were analyzed in 13 ET patients, stimulated in both the VIM and the PSA in a randomized, crossover trial. Distances of PSA and VIM contacts to population-based DRTTs were calculated. The relationships between distance to DRTT and stimulation amplitude, as well as DBS efficiency (TRS improvement per amplitude) were investigated.ResultsPSA contacts were closer to the DRTT (p = 0.019) and led to a greater improvement in TRS hemi-scores (p = 0.005) than VIM contacts. Proximity to the DRTT was related to lower amplitudes (p < 0.001) and higher DBS efficiency (p = 0.017).ConclusionsDifferences in tremor outcome and stimulation parameters between contacts in the PSA and the VIM can be explained by their different distance to the DRTT.
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