Journal Article

FZJ-2020-01803

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Early-phase [18F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury

Beyer, L. ; Nitschmann, A. ; Barthel, H. ; van Eimeren, T.FZJ* ; Unterrainer, M. ; Sauerbeck, J. ; Marek, K. ; Song, M. ; Palleis, C. ; Respondek, G. ; Hammes, J. ; Barbe, M. T. ; Onur, Ö.FZJ* ; Jessen, F. ; Saur, D. ; Schroeter, M. L. ; Rumpf, J.-J. ; Rullmann, M. ; Schildan, A. ; Patt, M. ; Neumaier, B.FZJ* ; Barret, O. ; Madonia, J. ; Russell, D. S. ; Stephens, A. W. ; Roeber, S. ; Herms, J. ; Bötzel, K. ; Levin, J. ; Classen, J. ; Höglinger, G. U. ; Bartenstein, P. ; Villemagne, V. ; Drzezga, A.FZJ* ; Seibyl, J. ; Sabri, O. ; Brendel, M. (Corresponding author)

2020
Springer-Verl. Heidelberg [u.a.]

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Please use a persistent id in citations: http://hdl.handle.net/2128/26026  doi:10.1007/s00259-020-04788-w

Abstract: PurposeSecond-generation tau radiotracers for use with positron emission tomography (PET) have been developed for visualization of tau deposits in vivo. For several β-amyloid and first-generation tau-PET radiotracers, it has been shown that early-phase images can be used as a surrogate of neuronal injury. Therefore, we investigated the performance of early acquisitions of the novel tau-PET radiotracer [18F]PI-2620 as a potential substitute for [18F]fluorodeoxyglucose ([18F]FDG).MethodsTwenty-six subjects were referred with suspected tauopathies or overlapping parkinsonian syndromes (Alzheimer’s disease, progressive supranuclear palsy, corticobasal syndrome, multi-system atrophy, Parkinson’s disease, multi-system atrophy, Parkinson's disease, frontotemporal dementia) and received a dynamic [18F]PI-2620 tau-PET (0–60 min p.i.) and static [18F]FDG-PET (30–50 min p.i.). Regional standardized uptake value ratios of early-phase images (single frame SUVr) and the blood flow estimate (R1) of [18F]PI-2620-PET were correlated with corresponding quantification of [18F]FDG-PET (global mean/cerebellar normalization). Reduced tracer uptake in cortical target regions was also interpreted visually using 3-dimensional stereotactic surface projections by three more and three less experienced readers. Spearman rank correlation coefficients were calculated between early-phase [18F]PI-2620 tau-PET and [18F]FDG-PET images for all cortical regions and frequencies of disagreement between images were compared for both more and less experienced readers.ResultsHighest agreement with [18F]FDG-PET quantification was reached for [18F]PI-2620-PET acquisition from 0.5 to 2.5 min p.i. for global mean (lowest R = 0.69) and cerebellar scaling (lowest R = 0.63). Correlation coefficients (summed 0.5–2.5 min SUVr & R1) displayed strong agreement in all cortical target regions for global mean (RSUVr 0.76, RR1 = 0.77) and cerebellar normalization (RSUVr 0.68, RR1 = 0.68). Visual interpretation revealed high regional correlations between early-phase tau-PET and [18F]FDG-PET. There were no relevant differences between more and less experienced readers.ConclusionEarly-phase imaging of [18F]PI-2620 can serve as a surrogate biomarker for neuronal injury. Dynamic imaging or a dual time-point protocol for tau-PET imaging could supersede additional [18F]FDG-PET imaging by indexing both the distribution of tau and the extent of neuronal injury.

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Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)
2. Nuklearchemie (INM-5)
3. Molekulare Organisation des Gehirns (INM-2)

Research Program(s):

1. 572 - (Dys-)function and Plasticity (POF3-572) (POF3-572)

Appears in the scientific report 2020

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Database coverage:
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