Journal Article

FZJ-2020-02531

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Associations of air pollution and noise with local brain structure in a cohort of older adults.

Nußbaum, R.FZJ* ; Lucht, S. ; Jockwitz, C.FZJ* ; Moebus, S. ; Engel, M. ; Jöckel, K.-H. ; Caspers, S. (Corresponding author)FZJ* ; Hoffmann, B. (Corresponding author)

2020
Research Triangle Park, N.C. [u.a.]

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Please use a persistent id in citations: http://hdl.handle.net/2128/25271  doi:10.1289/EHP5859

Abstract: Despite the importance of understanding associations of air pollution and noise exposure with loss of neurocognitive performance, studies investigating these exposures and local brain structure are limited.We estimated associations of residential air pollution and noise exposures with neurocognitive test performance and the local gyrification index (lGI), a marker for local brain atrophy, among older adults.For n = 615 participants from the population-based 1000BRAINS study, based on the German Heinz Nixdorf Recall study, we assessed residential exposures to particulate matter ( PM 10 , PM 2.5 , PM 2.5 abs ), accumulation mode particle number ( PN AM ), and nitrogen oxides ( NO x , NO 2 ), using land-use regression and chemistry transport models. Weighted 24-h and nighttime noise were modeled according to the European noise directive. We evaluated associations of air pollution and noise exposure at the participants' 2006-2008 residential addresses with neurocognitive test performance and region-specific lGI values ( n = 590 ) from magnetic resonance imaging, both assessed in 2011-2015, using linear regression and adjusting for demographic and personal characteristics.Air pollution and noise were associated with language and short-term/working memory and with local atrophy of the fronto-parietal network (FPN), a functional resting-state network associated with these cognitive processes. For example, per 2 - μ g / m 3 PM 10 , local brain atrophy was more pronounced in the posterior brain regions of the FPN, with a - 0.02 [95% confidence interval (CI): - 0.04 , 0.00] lower lGI. In contrast, in the anterior regions of the FPN, weighted 24-h and nighttime noise were associated with less local brain atrophy [e.g., 0.02 (95% CI: 0.00, 0.04) for 10 dB (A) 24-h noise].Air pollution and noise exposures were associated in opposite directions with markers of local atrophy of the FPN in the right brain hemisphere in older adults, suggesting that both chronic air pollution and noise exposure may influence the physiological aging process of the brain. https://doi.org/10.1289/EHP5859.

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Contributing Institute(s):

1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)
2. JARA-BRAIN (JARA-BRAIN)

Research Program(s):

1. 571 - Connectivity and Activity (POF3-571) (POF3-571)
2. HBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907) (785907)

Appears in the scientific report 2020

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Agriculture, Biology and Environmental Sciences ; Current Contents - Life Sciences ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; National-Konsortium ; PubMed Central ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record

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