Journal Article

FZJ-2020-04751

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Formulation of Gelled Non-toxic Bicontinuous Microemulsions Stabilized by Highly Efficient Alkanoyl Methylglucamides

Peng, K. ; Preisig, N. ; Sottmann, T. ; Stubenrauch, C. (Corresponding author)

2020
ACS Publ. Washington, DC

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Please use a persistent id in citations: http://hdl.handle.net/2128/26293  doi:10.1021/acs.langmuir.0c02314

Abstract: Gelled non-toxic bicontinuous microemulsions have a great potential for transdermal drug delivery as the microemulsion facilitates the solubilization of both hydrophilic and hydrophobic drugs, while the gel network provides mechanical stability and thus an easy application on the skin. In our previous study, we formulated a gelled non-toxic bicontinuous microemulsion: we gelled the system H2O – IPM – Plantacare 1200 UP (C12G1.4) – 1,2-octanediol with the low molecular weight organogelator 1,3:2,4-dibenzylidene-D-sorbitol (DBS). However, a large amount of Plantacare 1200 UP (12 wt.%) is needed to form a bicontinuous microemulsion. To solve this problem, we studied a new class of surfactants, namely alkanoyl methylglucamides (MEGA), which has been rarely used for the formulation of microemulsions. The phase behavior of MEGA-8/10, MEGA-12/14-PC and MEGA-12/14-HC was compared with that of alkyl polyglucosides. We found that even with 2 wt.% MEGA-12/14-HC a bicontinuous microemulsion can be formed, which is 1/6 of the amount of Plantacare 1200 UP. The bicontinuous microstructure of the non-toxic microemulsion H2O – IPM – MEGA-12/14-HC – 1,2-octanediol was confirmed by small-angle neutron scattering (SANS). Furthermore, the phase boundaries remained unchanged when gelled by DBS. The rheological properties of the gel were studied by oscillatory shear rheometry. Finally, FFEM images show the coexistence of gel fibers and bicontinuous oil and water domains. These results suggest that the new gelled non-toxic bicontinuous microemulsion is an orthogonal self-assembled system.

Keyword(s): Polymers, Soft Nano Particles and Proteins (1st) ; Soft Condensed Matter (2nd)

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Contributing Institute(s):

1. JCNS-FRM-II (JCNS-FRM-II)
2. Neutronenstreuung (JCNS-1)
3. Heinz Maier-Leibnitz Zentrum (MLZ)

Research Program(s):

1. 6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623) (POF3-623)
2. 6G15 - FRM II / MLZ (POF3-6G15) (POF3-6G15)

Experiment(s):

1. KWS-1: Small angle scattering diffractometer (NL3b)

Appears in the scientific report 2020

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Database coverage:
; ; Clarivate Analytics Master Journal List ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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