Journal Article

FZJ-2020-05224

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Engineering of natural product biosynthesis in Pseudomonas putida

Loeschcke, A. (Corresponding author)FZJ* ; Thies, S.FZJ*

2020
Elsevier Science Amsterdam [u.a.]

This record in other databases:      

Please use a persistent id in citations: http://hdl.handle.net/2128/26883  doi:10.1016/j.copbio.2020.03.007

Abstract: Organisms from all kingdoms of life represent a rich source for valuable natural products with various applications. Microbial systems are useful to implement the expression of respective biosynthetic genes and establish the production and effective access to natural products, or to elucidate the biochemistry of the underlying pathways. Pseudomonas putida, a Gram-negative soil bacterium, appears to be particularly suitable for natural product biosynthesis because of an advantageous intrinsic metabolism and a remarkable tolerance toward various xenobiotics. This article presents the current state of engineering P. putida for the biosynthesis of rhamnolipids, terpenoids, polyketides, non-ribosomal peptides, and products from amino acid metabolism. Technological advances facilitating chromosomal integration and expression of biosynthetic genes, and smart metabolic engineering are key to success.

---

Contributing Institute(s):

1. Institut für Molekulare Enzymtechnologie (HHUD) (IMET)

Research Program(s):

1. 583 - Innovative Synergisms (POF3-583) (POF3-583)

Appears in the scientific report 2020

---

Database coverage:
; ; ; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---