Journal Article

FZJ-2021-00990

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The natural axis of transmitter receptor distribution in the human cerebral cortex

Goulas, A. (Corresponding author) ; Changeux, J. P. ; Wagstyl, K. ; Amunts, K.FZJ* ; Palomero-Gallagher, N.FZJ* ; Hilgetag, C. C.

2021
National Acad. of Sciences Washington, DC

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Please use a persistent id in citations: http://hdl.handle.net/2128/27139  doi:10.1073/pnas.2020574118

Abstract: Transmitter receptors constitute a key component of the molecular machinery for intercellular communication in the brain. Recent efforts have mapped the density of diverse transmitter receptors across the human cerebral cortex with an unprecedented level of detail. Here, we distill these observations into key organizational principles. We demonstrate that receptor densities form a natural axis in the human cerebral cortex, reflecting decreases in differentiation at the level of laminar organization and a sensory-to-association axis at the functional level. Along this natural axis, key organizational principles are discerned: progressive molecular diversity (increase of the diversity of receptor density); excitation/inhibition (increase of the ratio of excitatory-to-inhibitory receptor density); and mirrored, orderly changes of the density of ionotropic and metabotropic receptors. The uncovered natural axis formed by the distribution of receptors aligns with the axis that is formed by other dimensions of cortical organization, such as the myelo- and cytoarchitectonic levels. Therefore, the uncovered natural axis constitutes a unifying organizational feature linking multiple dimensions of the cerebral cortex, thus bringing order to the heterogeneity of cortical organization.

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Contributing Institute(s):

1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)

Research Program(s):

1. 525 - Decoding Brain Organization and Dysfunction (POF4-525) (POF4-525)
2. HBP SGA1 - Human Brain Project Specific Grant Agreement 1 (720270) (720270)
3. HBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907) (785907)
4. HBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539) (945539)

Appears in the scientific report 2021

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Database coverage:
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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Preprint Goulas, A. ; Changeux, J. P. ; Wagstyl, K. ; Amunts, K.FZJ* ; Palomero-Gallagher, N.FZJ* ; Hilgetag, C. C.
The natural axis of transmitter receptor distribution in the human cerebral cortex
bioRxiv beta (2020) [10.1101/2020.09.28.316646]2020   Files  Fulltext by OpenAccess repository BibTeX | EndNote: XML, Text | RIS

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