Journal Article

FZJ-2021-00994

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Organization of the Macaque Monkey Inferior Parietal Lobule Based on Multimodal Receptor Architectonics

Niu, M. (Corresponding author)FZJ* ; Jankovic-Rapan, L.FZJ* ; Funck, T.FZJ* ; Froudist-Walsh, S. ; Zhao, L.FZJ* ; Zilles, K. ; Palomero-Gallagher, N. (Corresponding author)FZJ*

2021
Academic Press Orlando, Fla.

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Please use a persistent id in citations: doi:10.1016/j.neuroimage.2021.117843

Abstract: The macaque monkey inferior parietal lobe (IPL) is a structurally heterogeneous brain region, although the number of areas it contains and the anatomical/functional relationship of identified subdivisions remains controversial. Neurotransmitter receptor distribution patterns not only reveal the position of the cortical borders, but also segregate areas associated to different functional systems. Thus we carried out a multimodal quantitative analysis of the cyto- and receptor architecture of the macaque IPL to determine the number and extent of distinct areas it encompasses. We identified four areas on the IPL convexity arranged in a caudo-rostral sequence, as well as two areas in the parietal operculum, which we projected onto the Yerkes19 surface. We found rostral areas to have relatively smaller receptor fingerprints than the caudal ones, which is in an agreement with the functional gradient along the caudo-rostral axis described in previous studies. The hierarchical analysis segregated IPL areas into two clusters: the caudal one, contains areas involved in multisensory integration and visual-motor functions, and rostral cluster, encompasses areas active during motor planning and action-related functions. The results of the present study provide novel insights into clarifying the homologies between human and macaque IPL areas. The ensuing 3D map of the macaque IPL, and the receptor fingerprints are made publicly available to the neuroscientific community via the Human Brain Project and BALSA repositories for future cyto- and/or receptor architectonically driven analyses of functional imaging studies in non-human primates.

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Contributing Institute(s):

1. Strukturelle und funktionelle Organisation des Gehirns (INM-1)

Research Program(s):

1. 525 - Decoding Brain Organization and Dysfunction (POF4-525) (POF4-525)
2. HBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907) (785907)
3. HBP SGA3 - Human Brain Project Specific Grant Agreement 3 (945539) (945539)
4. 3D-MMA - 3D-MMA-Gradienten der Verteilung multipler Transmitterrezeptoren in der Hirnrinde als Grundlage verteilter kognitiver, sensorischer und motorischer Funktionen (BMBF-01GQ1902) (BMBF-01GQ1902)
5. HIBALL - Helmholtz International BigBrain Analytics and Learning Laboratory (HIBALL) (InterLabs-0015) (InterLabs-0015)

Appears in the scientific report 2021

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