Journal Article

FZJ-2021-01367

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Brain pathology recapitulates physiology: A network meta-analysis

Vanasse, T. J. (Corresponding author) ; Fox, P. T. ; Fox, P. M. ; Cauda, F. ; Costa, T. ; Smith, S. M. ; Eickhoff, S. B.FZJ* ; Lancaster, J. L.

2021
Springer Nature London

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Please use a persistent id in citations: http://hdl.handle.net/2128/27850  doi:10.1038/s42003-021-01832-9

Abstract: Network architecture is a brain-organizational motif present across spatial scales from cell assemblies to distributed systems. Structural pathology in some neurodegenerative disorders selectively afflicts a subset of functional networks, motivating the network degeneration hypothesis (NDH). Recent evidence suggests that structural pathology recapitulating physiology may be a general property of neuropsychiatric disorders. To test this possibility, we compared functional and structural network meta-analyses drawing upon the BrainMap database. The functional meta-analysis included results from >7,000 experiments of subjects performing >100 task paradigms; the structural meta-analysis included >2,000 experiments of patients with >40 brain disorders. Structure-function network concordance was high: 68% of networks matched (pFWE < 0.01), confirming the broader scope of NDH. This correspondence persisted across higher model orders. A positive linear association between disease and behavioral entropy (p = 0.0006;R2 = 0.53) suggests nodal stress as a common mechanism. Corroborating this interpretation with independent data, we show that metabolic 'cost' significantly differs along this transdiagnostic/multimodal gradient.

Note: This work was supported by the National Institute of Mental Health of the U.S. NationalInstitute of Health under award number R01 MH074457; the National Institute ofNeurological Disorders and Stroke of the U.S. National Institutes of Health under AwardNumber F32 NS114034; the U.S. Department of Defense, Defense Health Program,Psychological Health and Traumatic Brain Injury Research Program under the Consortiumto Alleviate PTSD (CAP) award number W81XWH-13-2-0065; and the U.S.Department of Veterans Affairs, Office of Research & Development, Clinical ScienceResearch & Development Service under award numer I01CX001136-01. The content issolely the responsibility of the authors and does not necessarily represent the officialviews of these funding agencies.

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Contributing Institute(s):

1. Gehirn & Verhalten (INM-7)

Research Program(s):

1. 525 - Decoding Brain Organization and Dysfunction (POF4-525) (POF4-525)

Appears in the scientific report 2021

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