Journal Article

FZJ-2021-02090

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Unravelling Magnetic Nanochain Formation in Dispersion for In Vivo Applications

Nandakumaran, N.FZJ* ; Barnsley, L. ; Feoktystov, A.FZJ* ; Ivanov, S. A. ; Huber, D. L. ; Fruhner, L. S.FZJ* ; Leffler, V. ; Ehlert, S.FZJ* ; Kentzinger, E.FZJ* ; Qdemat, A. ; Bhatnagar, T.FZJ* ; Rücker, U.FZJ* ; Wharmby, M. T. ; Cervellino, A. ; Dunin-Borkowski, R. E.FZJ* ; Brückel, T.FZJ* ; Feygenson, M. (Corresponding author)FZJ*

2021
Wiley-VCH Weinheim

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Please use a persistent id in citations: http://hdl.handle.net/2128/28165  doi:10.1002/adma.202008683

Abstract: Self-assembly of iron oxide nanoparticles (IONPs) into 1D chains is appealing, because of their biocompatibility and higher mobility compared to 2D/3D assemblies while traversing the circulatory passages and blood vessels for in vivo biomedical applications. In this work, parameters such as size, concentration, composition, and magnetic field, responsible for chain formation of IONPs in a dispersion as opposed to spatially confining substrates, are examined. In particular, the monodisperse 27 nm IONPs synthesized by an extended LaMer mechanism are shown to form chains at 4 mT, which are lengthened with applied field reaching 270 nm at 2.2 T. The chain lengths are completely reversible in field. Using a combination of scattering methods and reverse Monte Carlo simulations the formation of chains is directly visualized. The visualization of real-space IONPs assemblies formed in dispersions presents a novel tool for biomedical researchers. This allows for rapid exploration of the behavior of IONPs in solution in a broad parameter space and unambiguous extraction of ​the parameters of the equilibrium structures. Additionally, it can be extended to study novel assemblies formed by more complex geometries of IONPs.

Keyword(s): Magnetic Materials (1st) ; Condensed Matter Physics (2nd) ; Magnetism (2nd)

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Contributing Institute(s):

1. Streumethoden (JCNS-2)
2. Streumethoden (PGI-4)
3. JARA-FIT (JARA-FIT)
4. Neutronenstreuung (JCNS-1)
5. JCNS-FRM-II (JCNS-FRM-II)
6. Physik Nanoskaliger Systeme (ER-C-1)

Research Program(s):

1. 632 - Materials – Quantum, Complex and Functional Materials (POF4-632) (POF4-632)
2. 6G4 - Jülich Centre for Neutron Research (JCNS) (FZJ) (POF4-6G4) (POF4-6G4)

Experiment(s):

1. KWS-1: Small angle scattering diffractometer (NL3b)

Appears in the scientific report 2021

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Engineering, Computing and Technology ; Current Contents - Physical, Chemical and Earth Sciences ; DEAL Wiley ; Essential Science Indicators ; IF >= 25 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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