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| Hauptseite > Publikationsdatenbank > Progress report on biomaterials |
| Hauptseite > Publikationsdatenbank > Progress report on biomaterials |
| Book | FZJ-2021-02147 |
;
1993
Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag
Jülich
ISBN: 3-89336-111-1
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Please use a persistent id in citations: http://hdl.handle.net/2128/28491
Abstract: Initiated by the Rheinisch-Westfälische Technische Hochschule Aachen national and international activities have been started on a common project on biomaterials. In Germany regional groups as the "Arbeitsgemeinschaft Biowrkstoffe des Landes Nordrhein-Westfalen" and the "Thüringer Arbeitsgemeinschaft Biomaterialien" have been formed including universities as the Rheinisch-Westfalische Technische Hochschule Aachen, the Universität- Gesamthochschule Essen or the Friedrich-Schiller-Universität Jena, hospitals and industrie as Keramed Hermsdorf, for example. Supported by the Federal Government of Germany as well as the State Government of Nordrhein-Westfalen a "Graduiertenkolleg" was established in the frame of the "Arbeitsgemeinschaft Biowerkstoffe des Landes Nordrhein-Westfalen", in which 17 postgraduates together with 10 university-lecturers develop both an interdisziplinary teaching program and a research and development (r+d)-concept "biomaterials", on the basis of which the doctorate projects of the postgraduates are performed. This program was linked right from the beginning with bilateral cooperation between Germany and former Yugoslavia and internationally extended to Greece and Italy in the frame of Eureka-Project 294 on biomaterials. The present first progress report - whichcontains english and gennan written contributions - presents results and describes the above mentioned research concept in its chapter II. The importance of orthopaedic implants has increased steadily over the last years. Though the success rate of these operations is relatively high, they suffer from one major disadvantage: the life span of, for example, a total hip replacement prosthesis, is only about ten years. Mostly, the reason for failure of orthopaedic prostheses is loosening, due to biomechanical inadequacies and/or factors concerning biocompatibility. Important aspects in biomaterials research are therefore the microstructure and the mechanical behaviour of the bone-implant interface. The aim of the work presented in chapter III is the combination of preparation methods for light and electron rnicroscopy from materials science and histology to minirnize artefacts inthe "composite specimens" of hard tissue and different biomaterials. In a first step, hard tissue has been exarnined on its own. After a general introduction, chapter III presents basic considerations to be kept in mind whendealing with biomaterials. The most important biomaterials and fundamental aspects of their behaviour when implanted in the human body are shortly explained. The structure and microstructure of bone as one component of the composite system mentioned above are described followed by an introduction to histological preparation focusing on methods for undecalcified bone. Basic features of the scanning electron rnicroscope are explained before the reader is introduced to the materials and methods used. Finally own results are presented taking into account both histological and materials science aspects. The preparation method best suited for reflected light and electron microscopy of bone is the following: The fixed bone is embedded in a fast hardening resin - as used in rnicrostructural analysis - for grinding and polishing according to a scheme of preparation in microstructural analysis. Subsequently, the resin is carefully removed and, after dehydration in an ascending alcohol series, the specimens are critical point dried via acetone and carbondioxide. Damaging influences during preparation and examination in the scanning electron microscope are largely excluded. Scanning electron rnicroscopy can be perfonned in the backscattered electron mode with an accelerating voltage of 25 kilovolt (kV) or in the secondary electron mode with an accelerating voltage of 5 kV. A new preparation method for bone for transmission electron microscopy (TEM) -exarnination by dimpling a bone disc has been tested. Certain areas of special interest can be detected more reliably. First experiments have been promising, further exarnination is necessary however. The results presented above [...]
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