Journal Article

FZJ-2021-02871

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Regional locus coeruleus degeneration is uncoupled from noradrenergic terminal loss in Parkinson’s disease

Doppler, C. E. J. (Corresponding author)FZJ* ; Kinnerup, M. B. ; Brune, C. ; Farrher, E.FZJ* ; Betts, M. ; Fedorova, T. D. ; Schaldemose, J. L. ; Knudsen, K. ; Ismail, R. ; Seger, A. D.FZJ* ; Hansen, A. K. ; Stær, K. ; Fink, G. R.FZJ* ; Brooks, D. J. ; Nahimi, A. ; Borghammer, P. ; Sommerauer, M.FZJ*

2021
Oxford Univ. Press Oxford

This record in other databases:      

Please use a persistent id in citations: http://hdl.handle.net/2128/28859  doi:10.1093/brain/awab236

Abstract: Previous studies have reported substantial involvement of the noradrenergic system in Parkinson’s disease. Neuromelanin-sensitive MRI sequences and PET tracers have become available to visualize the cell bodies in the locus coeruleus and the density of noradrenergic terminal transporters.Combining these methods, we investigated the relationship of neurodegeneration in these distinct compartments in Parkinson’s disease. We examined 93 subjects (40 healthy controls and 53 Parkinson’s disease patients) with neuromelanin-sensitive turbo spin-echo MRI and calculated locus coeruleus-to-pons signal contrasts. Voxels with the highest intensities were extracted from published locus coeruleus coordinates transformed to individual MRI. To also investigate a potential spatial pattern of locus coeruleus degeneration, we extracted the highest signal intensities from the rostral, middle, and caudal third of the locus coeruleus. Additionally, a study-specific probabilistic map of the locus coeruleus was created and used to extract mean MRI contrast from the entire locus coeruleus and each rostro-caudal subdivision. Locus coeruleus volumes were measured using manual segmentations.

---

Contributing Institute(s):

1. Kognitive Neurowissenschaften (INM-3)
2. Physik der Medizinischen Bildgebung (INM-4)

Research Program(s):

1. 5251 - Multilevel Brain Organization and Variability (POF4-525) (POF4-525)

Appears in the scientific report 2021

---

Database coverage:
; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; Nationallizenz ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---